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KMID : 0191120230380170135
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Journal of Korean Medical Science
2023 Volume.38 No. 17 p.135 ~ p.135
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Injectable Poloxamer Hydrogel Formulations for Intratympanic Delivery of Dexamethasone
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Thi Phuc Le
Yang Yu
Cho Ik-Sung
Suh Eun-Yeong
Kwon Hyuk-Chan
Shin Sun-Ae
Park Yong-Ho
Huh Kang-Moo
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Abstract
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Background : In this study, we prepared and evaluated an injectable poloxamer (P407) hydrogel formulation for intratympanic (IT) delivery of dexamethasone (DEX).
Methods : DEX-loaded P407 hydrogels were characterized in terms of thermogelation, drug loading capacities, particle size, and drug release. The in vivo toxicity and drug absorption of the DEX-loaded P407 formulation after IT injection were evaluated using an animal model by performing histopathological analysis and drug concentration measurements.
Results : The P407 hydrogel effectively solubilized hydrophobic DEX and demonstrated a sustained release compared to the hydrophilic DEX formulation. The in vivo study showed that the hydrogel formulation delivered considerable drug concentrations to the inner ear and displayed a favorable safety profile without apparent cytotoxicity or inflammation.
Conclusion : P407 hydrogel can be useful as an injectable inner ear delivery formulation for hydrophobic drugs due to their biocompatibility, drug-solubilizing capacity, thermogelation, and controlled release.
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KEYWORD
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Poloxamer, Dexamethasone, Injectable Hydrogel, Intratympanic Injection, Inner Ear Delivery
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